Fertility Treatment · Portland, Oregon
Intrauterine PRP therapy
A cutting-edge approach to improving uterine receptivity for patients facing implantation challenges or thin endometrial lining.
Platelet-rich plasma (PRP) is a concentration of growth factors derived from your own blood. When introduced directly into the uterine cavity, it can stimulate tissue regeneration, promote healthy endometrial growth, and create a more receptive environment for embryo implantation.
Intrauterine PRP is an autologous treatment — meaning it uses your own platelets — making it well-tolerated and minimally invasive. It is typically performed as part of a fertility treatment cycle and takes only a few minutes to administer.
How the procedure works
A small sample of your blood is collected, similar to a routine blood test.
The sample is spun to concentrate the platelets and growth factors into a small volume of plasma.
The PRP is gently instilled into the uterine cavity using a thin catheter, similar to an IUI procedure.
You rest briefly before leaving. Lining thickness and response are monitored via ultrasound in the days following.
Conditions it may help
Thin endometrial lining
Inadequate endometrial thickness for implantation
A lining of at least 7–8 mm is generally considered necessary for embryo implantation. Some patients fail to reach adequate thickness despite estrogen supplementation. PRP introduces growth factors — including VEGF, PDGF, and EGF — that stimulate endometrial proliferation and improve blood flow to the uterine lining.
Several studies have reported significant improvements in lining thickness in patients who were previously unresponsive to standard hormonal protocols, allowing frozen embryo transfer cycles to proceed.
Emerging clinical evidenceAsherman's syndrome
Intrauterine adhesions (scar tissue) affecting the uterine cavity
Asherman's syndrome involves the formation of adhesions or fibrosis within the uterine cavity, often following a dilation and curettage (D&C), infection, or uterine surgery. These adhesions can distort the cavity, reduce lining thickness, and significantly impair fertility.
Following hysteroscopic adhesiolysis, intrauterine PRP may support endometrial regeneration by delivering concentrated growth factors to areas of scarred or atrophied tissue, potentially reducing recurrence of adhesions and improving lining quality.
Used adjunctively post-surgeryRecurrent implantation failure
Failure to achieve pregnancy after multiple high-quality embryo transfers
Recurrent implantation failure (RIF) is generally defined as the failure of two or more good-quality embryo transfers. While embryo quality plays a role, uterine receptivity — including endometrial immune environment, vascularity, and cellular signaling — is equally important.
PRP may improve endometrial receptivity by modulating the local immune response, enhancing endometrial vascularity, and improving the expression of implantation markers. It is often considered when standard workup has not identified a correctable cause.
Investigated in IVF/FET cyclesWho may be a candidate
Patients who have not responded to standard hormonal priming with adequate endometrial development.
Women recovering from hysteroscopy for Asherman's or other intrauterine procedures.
Patients with high-quality embryos and no identified uterine abnormality who have experienced repeated transfer failures.
Used as an adjunct therapy in the days leading up to a frozen embryo transfer (FET) to optimize the uterine environment.
Ready to learn if intrauterine PRP is right for you?
Schedule a consultation →Intrauterine PRP is considered an emerging treatment and is not yet a standard of care. While early research is promising, larger randomized controlled trials are ongoing. Results vary by individual. This page is intended for informational purposes and does not constitute medical advice. Please consult with your provider to determine whether this treatment is appropriate for your specific situation.